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Opioid receptors are a group of inhibitory G protein coupled receptors. Opioids exert their pharmacological actions through three opioid receptors called Mu, Kappa, and Delta.
Ibogaine works on the Kappa and Mu receptor sites. Through neurological actions, Ibogaine in therapeutic amounts halts the effects and resets the chemical memory of the opiates which ends withdrawal symptoms instantly. This also allows for a reset and rebalancing in the neurochemistry of the brain. This is Ibogaine Science.
Once Ibogaine is ingested and metabolized through the liver its metabolite Noribogaine works to combat the effects of the addiction by resetting the Mu and Kappa receptor sites in the brain. The receptor site reset allows for the opiates on the receptor sites to be erased. It relieves the post acute withdrawal symptoms and re-balances the natural dopamine and serotonin levels. Balancing serotonin levels reduces depression, anxiety, stabilizes mood, and helps regulate sleep.
Changed behavior, healthy lifestyle and self care are implemented. The re-balancing of serotonin levels and dopamine in the brain has a major impact on PTSD, depression, anxiety, and mood instability. Ibogaine has a spiritual affect on the mind. Inner peace and acceptance of oneself with an overall sense of self love and mental clarity occur.
Noribogaine is lipophilic which means its stored in the fat tissue. Its stored up to approximately 90 days depending the metabolism of each individual. This allows for an interruption in the addiction, called the addiction interrupter.
Serotonin receptors in the brain are activated. Serotonin is the key hormone that stabilizes our mood, feelings of wellbeing, and happiness. Balancing serotonin and dopamine levels helps to reduce depression, anxiety, regulates sleep, and helps balance out our emotions. Ibogaine can change the neuroplasticity of the brain by re-directing and connecting neuroreceptor sites. This is Ibogaine science.
Ibogaine is the primary active alkaloid in the Tabernathe iboga plant which is native to West Africa’s Gabon and Cameroon regions. It is a plant medicinal substance with a long history of ceremonial and multiple entheogenic medicinal treatments. The hallucinogenic and healing aspects properties were adopted by the people of Gabon as a Bwiti practice. Bwiti is a spiritual and ceremonial ritual that's centered around the use of Iboga. It is presently popular as a sacred medicine . The Bwiti tribe have used Iboga as a sacrament for thousands of years.
Presently in the western culture we have isolated the main alkaloid of the iboga plant called Ibogaine. Ibogaine has been used for years to treat drug and alcohol addiction. It also treats medical conditions that include PTSD, depression, and anxiety. It is also used for spiritual re-balancing as it has affects of balancing the natural endorphins in our body.
The scientific breakthrough occurred in 1962 when Howard Lotsof accidentally discovered the anti-addictive effects of Ibogaine. Lotsof was a heroin addict and took ibogaine for recreational use. When the effects wore off, he no longer had any post acute withdrawal symptoms or any desire or cravings to use heroin. He had been an drug addict for over 25 years and after taking Ibogaine it changed his life into a life of sobriety. He then began a life journey to educate and treat other addicts and was very successful and helped hundreds of addicts get sober.
Lotsof went on to try commercialize Ibogaine with many hurdles along the way and was unable to get enough money and support and eventually was blocked by the FDA and groups that did not want ibogaine to become commercialized. Ibogaine worked, not a cure, but a 100 percent pain free detoxification and known as a addiction interruptor. Ibogaine has helped thousands of people gain sobriety through out the years. As of today Ibogaine in the US is classified as a schedule one drug.
Just in the last few years Ibogaine is finally gaining credibility and acceptance due to increased clinical studies and companies investing money in research. This is very positive for the future of Ibogaine. The goal is to change Ibogaine to a schedule two class medication in the US so it can be used safely and effectively to help thousands of people.
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